- Fairfield Inn & Suites Santee9.3Santee
- Travelodge by Wyndham Orangeburg7.3Orangeburg
- Red Roof Inn St George, SC6.2Saint George
- Econo Lodge St George6.0Saint George
- Tru By Hilton Orangeburg8.5Orangeburg
- Holiday Inn Express & Suites Orangeburg by IHG8.2Orangeburg
- Baymont by Wyndham Orangeburg North5.5Orangeburg
- Hampton Inn Manning7.9Manning
- Baymont Inn & Suites7.4Manning
- Hampton Inn Santee-I-959.1Santee
- Baymont by Wyndham Santee7.3Santee
- Sleep Inn Orangeburg7.8Orangeburg
- Comfort Inn & Suites Orangeburg7.2Orangeburg
- Travelodge by Wyndham Santee6.8Santee
- Comfort Inn & Suites Santee I-957.8Santee
- Winton Inn & SuitesBarnwell5.0
- Hampton Inn & Suites Orangeburg, SC8.8Orangeburg
- SureStay Hotel by Best Western Manning8.1Manning
- Motel 6 Saint George, SC – I-957.0Saint George
- Peach Tree Inn6.5Saint George
- Quality Inn & Suites Orangeburg5.5Orangeburg
- Days Inn by Wyndham Orangeburg South5.5Orangeburg
- Holiday Inn Santee by IHG7.2Santee
- Days Inn by Wyndham Orangeburg5.2Orangeburg
- Days Inn by Wyndham St George7.4Saint George
- Best Western PLUS Santee Inn8.5Santee
- Super 8 by Wyndham Orangeburg Near I-266.4Orangeburg
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