- Comfort Suites Florence I-957.9Florence
- Staybridge Suites - Florence Center by IHG9.1Florence
- Comfort Inn & Suites8.7Florence
- Holiday Inn Express & Suites Florence by IHG8.2Florence
- La Quinta by Wyndham Florence7.4Florence
- Days Inn by Wyndham Florence/I-95 North6.1Florence
- Howard Johnson by Wyndham Florence8.1Florence
- Red Roof Inn Florence - Civic Center6.1Florence
- Microtel Inn & Suites by Wyndham Florence6.2Florence
- Country Inn & Suites by Radisson, Florence, SC7.0Florence
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